Conclusion
The present results again demonstrate a beneficial effect of gentamicin on chronic foreign body reaction by modulation of MMP-2 gene transcription that may be a feasible approach to optimize mesh integration into the abdominal wall, and ultimately to improve the long-term outcome following hernia mesh repair. However, animal models have their natural limitations, and results cannot be extrapolated directly to the situation in humans. Therefore, clinical trials are needed to verify the suggested beneficial effect of gentamicin, and further experimental studies are needed to elucidate the exact molecular mechanisms of gentamicin on MMP-2 gene transcription.