A Genetic Cause of an Uncommon Lipidemia
Dr. Ali Torkamani looks at a mutation that causes an uncommon familial lipidemia and discusses its clinical relevance to the general population.
Category : Genetic Test : Health & Medical
Pharmacogenetics-Based Warfarin Dosing in Children
This review describes the two main types of pharmacogenetic-based warfarin dose prediction models and their applicability to children. What are their respective advantages and limitations?
Pharmacogenetics of Statins: Achievements and Perspectives
There is large variability in clinical response to statin therapy. This review examines genetic factors which may contribute to the lipid-lowering effectiveness of statins and their side effects.
Transporter-mediated Drug-Drug Interactions
Drug-drug interactions are a serious clinical issue. This article looks at the mechanisms of interactions of selected intestinal, hepatic and renal drug transporters.
EGFR TKIs in Non-Asians With NSCLC: A New Treatment Paradigm
Firstline EGFR TKIs in Asians with mutation-positive NSCLC are known to improve outcomes. Dr. Maurie Markman reviews data on their use in Europeans and considers the impact on treatment protocols.
Hepatotoxicity Caused by Tyrosine Kinase Inhibitors
This review presents pharmacogenetic comparisons of two tyrosine kinease inhibitors which have associated risk of serious liver injury. By what mechanisms do they induce liver toxicity?
Next-Generation Sequencing and Large Genome Assemblies
This article reviews the state of the art in next-generation genome sequencing platforms, which offer massive increases in both time and cost-effectiveness over older methods.
First-Line Targeted Therapy for Poor PS NSCLC
Dr. Maurie Markman comments on a study published in the Journal of Clinical Oncology demonstrating the benefit of anti-EGFR therapy in this difficult-to-treat population.
Redefining Personalized Medicine in the Primary Care Setting
What should a personalized medicine approach be in a primary care practice? Dr. Scott Joy considers both patient and provider perspectives and their impact on the practice of medicine moving forward.
Pharmacogenetics of Statins: Achievements and Perspectives
There is large variability in clinical response to statin therapy. This review examines genetic factors which may contribute to the lipid-lowering effectiveness of statins and their side effects.
How Common Are Drug and Gene Interactions?
Drug-drug interactions are a widely recognized cause of adverse drug reactions, but drug-gene interactions can be a potential source of ADRs as well. How common are they?
A Discussion on Genome-Wide Associations in Pharmacogenomics
Professor Alison Motsinger-Reif of the Bioinformatics Research Center at North Carolina State University discusses how genome-wide association studies have changed research in pharmacogenomics.
The Role of Pharmacogenomics in Kidney Transplantation
A major challenge in kidney transplant is the prediction of allograft rejection and immunosuppressive drug response. What can pharmacogenomics contribute?
Explaining Variability in Plasma Triglyceride Levels Through Rare Variants
A Nature Genetics paper identifies rare variants that help explain heritability of hypertriglyceridemia, but the knowledge gain is only incremental. Dr. Ali Torkamani explains why.
Pharmacogenomics With Antidepressants in the STAR*D Study
Read this comprehensive review of pharmacogenomic implications of this landmark study.
How Common Are Drug and Gene Interactions?
Drug-drug interactions are a widely recognized cause of adverse drug reactions, but drug-gene interactions can be a potential source of ADRs as well. How common are they?
A Urinary Biomarker Associated With CYP2D6 Activity
CYP2D6 is crucial for the metabolism of many drugs, but currently phenotyping requires administration of a probe drug. Could a urinary biomarker provide a noninvasive method of CYP2D6 phenotyping?
Targeted Therapy for Papillary RCC: An Uncommon Approach
Dr. Maurie Markman considers a new therapy that targets an uncommon mutation in the uncommon papillary subtype of renal cell carcinoma.
It's All in the Family (History)
For effective assessments of personal disease risk, nothing beats family history.
Pharmacogenetics of Chronic Obstructive Pulmonary Disease
What insights can pharmacogenetic studies give us as to the various phenotypes of COPD and their differing responses to currently existing and future therapies?