Renal Cell Carcinoma Development and miRNAs
The majority of renal cell carcinoma cases are detected accidentally, and often at a late stage. Could miRNAS serve as potential biomarkers for diagnosis and prognosis?
Category : Genetic Test : Health & Medical
Pharmacogenetics of Antidepressant Drugs
This review summarizes recent progress in isolating biomarkers which might predict which patients will have the greatest benefit from antidepressant therapy for depression and other mood disorders.
Evaluating the Benefits of a Genetic Risk Score in Predicting Cardiovascular Disease
Drs. Deepak Voora and Svati Shah comment on a study published in JAMA looking at the additive benefit of a genetic risk score in predicting CV disease.
TPL and Drug Sensitivity of Resistant Leukemia Cell Lines
This study takes a look into the enhancing effect of triptolide (TPL) in drug-resistant myeloid leukemia cell lines.
Transporter-mediated Drug-Drug Interactions
Drug-drug interactions are a serious clinical issue. This article looks at the mechanisms of interactions of selected intestinal, hepatic and renal drug transporters.
EGFR TKIs in Non-Asians With NSCLC: A New Treatment Paradigm
Firstline EGFR TKIs in Asians with mutation-positive NSCLC are known to improve outcomes. Dr. Maurie Markman reviews data on their use in Europeans and considers the impact on treatment protocols.
Hepatotoxicity Caused by Tyrosine Kinase Inhibitors
This review presents pharmacogenetic comparisons of two tyrosine kinease inhibitors which have associated risk of serious liver injury. By what mechanisms do they induce liver toxicity?
First-Line Targeted Therapy for Poor PS NSCLC
Dr. Maurie Markman comments on a study published in the Journal of Clinical Oncology demonstrating the benefit of anti-EGFR therapy in this difficult-to-treat population.
Redefining Personalized Medicine in the Primary Care Setting
What should a personalized medicine approach be in a primary care practice? Dr. Scott Joy considers both patient and provider perspectives and their impact on the practice of medicine moving forward.
Pharmacogenetics of Statins: Achievements and Perspectives
There is large variability in clinical response to statin therapy. This review examines genetic factors which may contribute to the lipid-lowering effectiveness of statins and their side effects.
How Common Are Drug and Gene Interactions?
Drug-drug interactions are a widely recognized cause of adverse drug reactions, but drug-gene interactions can be a potential source of ADRs as well. How common are they?
A Discussion on Genome-Wide Associations in Pharmacogenomics
Professor Alison Motsinger-Reif of the Bioinformatics Research Center at North Carolina State University discusses how genome-wide association studies have changed research in pharmacogenomics.
The Role of Pharmacogenomics in Kidney Transplantation
A major challenge in kidney transplant is the prediction of allograft rejection and immunosuppressive drug response. What can pharmacogenomics contribute?
Explaining Variability in Plasma Triglyceride Levels Through Rare Variants
A Nature Genetics paper identifies rare variants that help explain heritability of hypertriglyceridemia, but the knowledge gain is only incremental. Dr. Ali Torkamani explains why.
Pharmacogenomics With Antidepressants in the STAR*D Study
Read this comprehensive review of pharmacogenomic implications of this landmark study.
How Common Are Drug and Gene Interactions?
Drug-drug interactions are a widely recognized cause of adverse drug reactions, but drug-gene interactions can be a potential source of ADRs as well. How common are they?
A Urinary Biomarker Associated With CYP2D6 Activity
CYP2D6 is crucial for the metabolism of many drugs, but currently phenotyping requires administration of a probe drug. Could a urinary biomarker provide a noninvasive method of CYP2D6 phenotyping?
Targeted Therapy for Papillary RCC: An Uncommon Approach
Dr. Maurie Markman considers a new therapy that targets an uncommon mutation in the uncommon papillary subtype of renal cell carcinoma.
It's All in the Family (History)
For effective assessments of personal disease risk, nothing beats family history.
Pharmacogenetics of Chronic Obstructive Pulmonary Disease
What insights can pharmacogenetic studies give us as to the various phenotypes of COPD and their differing responses to currently existing and future therapies?