IL-13 was found to induce NHBE cell proliferation, and release of TGFα, in an ADAM17-dependent manner; however, this IL-13-induced proliferation did not appear to result solely from ADAM17 activation.
Current therapeutic strategies are mainly designed to induce relaxation of the pulmonary arteries, not to improve vascular remodeling that characterizes PAH. Will newer agents remodel the vasculature?
Military recruits in training are vulnerable to acute respiratory disease. This study documents adenovirus and RSV as important causes of acute respiratory illness among Royal Navy trainees.
Key findings of clinical studies in cystic fibrosis and current preclinical and clinical research aimed at further developing gene therapy for CF are described in this article.
The pathophysiological consequences of central sleep apnea on left ventricular structure and functions and the impact on the prognosis of heart failure are discussed.