Summary
Sornay-Rendu E, Karras-Guillibert C, Munoz F, Claustrat B, Chapurlat RD. Age determines longitudinal changes in body composition better than menopausal and bone status: the OFELY Study. J Bone Miner Res 2012;27:628-636. Level of evidence: II-3.
Researchers evaluated body composition changes in French women from the Os des Femmes de Lyon (OFELY) cohort. Premenopausal women (n = 145) had lower fat body mass and higher lean body mass, relative skeletal muscle mass index, and total body bone mineral content compared with postmenopausal women untreated with hormone therapy (n = 412) at baseline.
After 6 years, lean body mass and relative skeletal muscle mass index did not change, but there was a significant increase in fat mass and a decrease in total body bone mineral content in pre- (n = 88) and peri-menopausal (n = 44) women. In untreated postmenopausal women, fat body mass increased and other measures decreased. Menopause status was a significant determinant only for changes in total body bone mineral content, after controlling for age. Levels of P1NP in the highest quartile of women were associated with a greater decrease of lean body mass and relative skeletal muscle mass index, after controlling for age and menopausal status.