Conclusions
To sum up, in patients with septic shock titrating intravascular volume expansion with preload dependence indices did not change time to shock resolution but resulted in less daily fluids intake, including red blood cells, without worsening patient outcome.
Key Messages
In septic shock patients, titrating intravascular volume expansion with preload dependence indices may have no effect on time to shock resolution.
This strategy is, however, associated with a decrease in both the daily amount of intravascular fluids and red blood cell transfusion, with no outcome penalty.