Updated December 15, 2003.

by Mary Shomon

Jan 8, 2002 -- Last week, on New Year's Day, I was prescribed an antibiotic, Tequin (gatifloxacin), at a "Doc in the Box" urgent care walk-in clinic for a sinus infection. By January 2, I was having dizziness, tingling in my hands and knees, pains in my legs, weakness in my arms and legs. By January 3, shortness of breath started. I thought my symptoms might be related to my sinus infection, until I realized that they went away at night, and would start up again about an hour after taking my morning Tequin pill.


On January 4, I took my Tequin, the symptoms started up again, and I called the doctor, who told me to stop taking it further, and switched me to a more benign antibiotic. In the meantime, after four days in my system, I started having worsening shortening of breath, and difficulty swallowing, so I took two Benadryl, and called the doctor. He suggested a trip to the emergency room to see if I was having a potentially life-threatening anaphalactic allergic reaction.

I was not having a reaction that could close off my airway, but my airway was swollen, and I was kept on Benadryl for two days. In the meantime, the tingling, numbness, difficulty swallowing and other neurological symptoms continued. By January 5, I was feeling horrible, my memory was shot, and the tingling, numbness and diziness was still full steam. After a night-time emergency call to my regular physician, she suggested that I take some clonazepam (Klonopin), a mild tranquilizer, to see if that could calm down the overreactive nervous system.

Amazingly, within minutes, that calmed down the symptoms. The tranquilizer was soothing the nerves that had gotten aggravated by the Tequin reaction. At my doctor's recommendation, I've remained on the Klonopin since that time, while the symptoms gradually have subsided and finally gone away.

What I had was a dangerous -- and even potentially life-threatening-- drug reaction. Who knows what might have happened had I not taken the Benadryl -- an antihistimine -- when the shortness of breath and airway constriction began? What sorts of neurological implications could I have faced if I had stayed on a full 10-day course of Tequin?

Tequin is the brand name for gatifloxacin, one of the family of floroquinolone family of antibiotics. Others in this family include the now famous Cipro (ciprofloxacin), plus Floxin (ofloxacin), Levaquin (levofloxacin), and others.

Dizziness, headaches, seizures and psychosis are well known "adverse" effects of these antibiotics. What is not considered common in the literature, but is outlined in many patient forums and in a medical study of the side effects, is the various other neurological symptoms of these drugs, that can occur in as many as7% of patients. These symptoms include pins and needles, numbness, tingling, muscle and joint pain, palpitations, malaise, panic attacks, and anxiety. (Peripheral Neuropathy Associated with Fluoroquinolones, Jay S. Cohen, The Annals of Pharmacotherapy, 2001 December, Volume 35)

While the "Doc in the Box" doctor recognized that I was having some sort of reaction to the drug, he seemed someone incredulous that the symptoms were as debilitating as they were. My regular physician, however, knew immediately what I was going through. She herself had taken Tequin in the past, and said after two days of Alzheimer's-like cognitive effects, discontinued the drug. She immediately suggested the use of the clonazepam to help counteract the effects, which was a success in my case.

Reporting Adverse Reactions

I went ahead and decided that I should file an adverse effects report, because the FDA and drug companies should be held accountable for the negative effects of drugs, some of which are rushed through the approval process, leaving patients like msyelf to experience potentially debilitating side effects. So, when it comes to an adverse drug reaction, what do you do?

In 1993, the Food and Drug Administration (FDA) launched a major program, MedWatch, that was meant to encourage health professionals to increase their submission of adverse reaction reports. If you think you are having an adverse reaction to any drug, you should always report it to your doctor, so you can be switched to a safer drug, or a reduced dosage, to help alleviate your adverse response. More reporting of adverse effects will help save people's lives and health, by making doctors and patients aware of the potential effects of medicines.